Acute and Chronic Cough (Lung Biology in Health and Disease, by Anthony E. Redington, Alyn H. Morice
By Anthony E. Redington, Alyn H. Morice
A complete overview of the clinical and scientific facets of acute and protracted cough, this reference specializes in contemporary advancements in our realizing of the molecular biology of putative cough receptors, the neural mechanisms considering the afferent and efferent limbs, the significant processing of the cough reflex, and peptides and different elements which can mediate or modulate the cough reflex. With chapters wriitenby stated gurus within the box, this instruction manual covers present and power healing brokers, a variety of methodologies to degree cough reflex sensitivity, and scientific methods for the overview of persistent cough in adults and youngsters.
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Many aspects of TRPV1 modulation by phosphorylation remain to be explored, as the channel contains putative substrate sequences for other types of kinase and phosphatase in addition to those discussed here. 5 C becomes a strong activator of TRPV1. Protons act on TRPV1 to lower its heat threshold (from 43 C to body temperature) via the extracellular proton-binding site of the channel, as described earlier. Several other kinds of ligands released endogenously from tissues or from sensory neurons themselves can also activate TRPV1.
Prog Brain Res 1996; 113:143–151. 52. Jordt S-E, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci USA 2000; 97: 8134–8139. Molecular Biology of TRPV1 and Related Receptors 19 53. Jung J, Hwang SW, Kwak J, Lee S-Y, Kang C-J, Kim WB, Kim D, Oh U. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J Neurosci 1999; 19:529–538. 54. Numazaki M, Tominaga T, Toyooka H, Tominaga M. Direct phosphorylation of capsaicin receptor VR1 by protein kinase Ce and identification of two target serine residues.
Capsaicin, protons and heat: new excitement about nociceptors. Trends Pharmacol Sci 1999; 20:112–118. 23. Welch JM, Simon SA, Reinhart PH. The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. Proc Natl Acad Sci USA 2000; 97: 13889–13894. Molecular Biology of TRPV1 and Related Receptors 17 24. Premkumar LS, Agarwal S, Steffen D. Single-channel properties of native and cloned rat vanilloid receptors. J Physiol 2002; 545:107–117.