Acute Myelogenous Leukemia: Genetics, Biology and Therapy by Zeev Estrov (auth.), Lalitha Nagarajan (eds.)

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By Zeev Estrov (auth.), Lalitha Nagarajan (eds.)

Acute myelogenous leukemia (AML), is the most typical kind of leukemia in adults. AML is a dangerous type of malignancy, the analysis for which has no longer more desirable within the final twenty years. extra importantly, it's a malignancy that's noticeable in older adults, accordingly the variety of instances is probably going to upward push because the inhabitants a while.

Over the prior 15 years, genetic mechanisms underlying AML have started to spread. extra examine during this sector has helped determine key parts and features. as a result, precise remedy of AML is receiving a lot awareness. it's the desire of researchers that as with power myelogenous leukemia (CML), and the drug, Gleevec, a designated treatment for AML should be discovered.

"The potent therapy of acute myelogenous leukemia continues to be an exceptional problem. this article reports our realizing of the molecular and biologic foundation of the disorder. prime investigators tackle advances in prognostication and healing options that experience major promise."

Steven T. Rosen, M.D.
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J Clin Oncol. 2005;23(16S):(abstr 6546). 125. Olesen LH, Aggerholm A, Andersen BL, et al. Molecular typing of adult acute myeloid leukaemia: significance of translocations, tandem duplications, methylation, and selective gene expression profiling. Br J Haematol. 2005;131(4):457–467. 126. Petti MC, Mandelli F, Zagonel V, et al. Pilot study of 5-aza-20 -deoxycytidine (Decitabine) in the treatment of poor prognosis acute myelogenous leukemia patients: preliminary results. Leukemia. 1993;(7 suppl. 1):36–41.

These were the UK MRC (United Kingdom Medical Research Council) and SWOG (Southwest Oncology Group). They define three and four categories, respectively. In MRC, favorable prognoses include presence of t(8;21), inv 16, and t(15;17), irrespective of additional abnormalities [54]. The prognoses are adverse if the karyotype include at least five unrelated abnormalities (complex karyotype) or one of the following abnormalities, À5, del(5q), À7, abnormalities 3q. In SWOG, favorable abnormalities included t(8;21), inv 16, and t(15;17).

N. edu L. 1007/978-0-387-69259-3_3, Ó Springer ScienceþBusiness Media, LLC 2010 41 42 N. Palanisamy Acute Myeloid Leukemia (AML) As discussed extensively in other parts of this monograph, AML is characterized by the accumulation of immature bone marrow precursor in the marrow and peripheral blood. G-band karyotype analysis reveals clonal chromosome aberrations in more than 75% of patients [11,35]. Characteristic chromosome abnormalities include t (8; 21), inv (16) or t (16; 16), t (15; 17), and promiscuous translocations involving MLL gene at 11q23.

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