Biophysics

Behavioral Neurobiology of Bipolar Disorder and its by Husseini K. Manji, Carlos A. Zarate Jr.

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By Husseini K. Manji, Carlos A. Zarate Jr.

This publication bargains the main up to date information regarding learn surrounding the neurobiology of bipolar ailment in addition to at present on hand and novel healing thoughts. the amount has assembled a commonly revered crew of preclinical and medical researchers who convey their services to endure upon this disease by way of reviewing state of the art examine and medical proof concerning the pathophysiology and remedy of bipolar illness. Early chapters evaluation the direction and consequence and genetics of this hugely heritable , together with chapters on epigenetics and medical endophenotypes. a number of chapters supply a remarkably thorough and specific assessment of the neurobiology of the disease, together with what's identified from neuroimaging paintings and the advance of animal types. eventually, the booklet covers remedy recommendations for bipolar affliction, together with either conventional and novel therapeutics, in addition to non-pharmacological remedies. It bargains either researchers and clinicians key insights into this devastating disease.

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1). The first of these (Baum et al. 2008) implicated the gene diacylglycerol kinase eta (DGKH), which is known to be involved in pathways sensitive to lithium, a mood stabilizer frequently used to treat BPD. Subsequent studies (Ferreira et al. 2008; O’Donovan et al. 2008) have implicated novel genes (ANK3, CACNA1C, and ZNF804A) that suggest novel biological pathways. Reminiscent of the family studies that found increased rates of major depression among the relatives of individuals with BPD, one study found a locus that may be involved in both disorders (McMahon et al.

Am J Psychiatry 155(5):646 652 Keller MB (1988) The course of manic depressive illness. J Clin Psychiatry 49(Suppl):4 7 Keller MB, Lavori PW, Coryell W, Andreasen NC, Endicott J, Clayton PJ et al (1986) Differential outcome of pure manic, mixed/cycling, and pure depressive episodes in patients with bipolar illness. JAMA 255(22):3138 3142 Kessing LV, Hansen MG, Andersen PK, Angst J (2004) The predictive effect of episodes on the risk of recurrence in depressive and bipolar disorders a life long perspective.

Thus, comparing Genetics of Bipolar Disorder 21 MZ and DZ twins can parse environmental and genetic contributions to a phenotype. For BPD, it has been consistently observed that MZ twins have a much higher concordance for BPD than dizygotic twins. This difference in concordance leads to heritability estimates from large twin studies in the range of 59 87% (Bertelsen et al. 1977; Cardno et al. 1999; Edvardsen et al. 2008; Kendler 1993, 2001). 2 Family Studies Family studies have also helped define the range of clinical phenotypes present in the relatives of people with BPD.

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