Biomedical Polymers and Polymer Therapeutics by Emo Chiellini, Junzo Sunamoto, Claudio Migliaresi, Raphael
By Emo Chiellini, Junzo Sunamoto, Claudio Migliaresi, Raphael M. Ottenbrite, Daniel Cohn
Court cases of the 3rd overseas Symposium on Frontiers in Biomedical Polymers together with Polymer Therapeutics: From Laboratory to medical perform, held could 23-27, 1999, in Shiga, Japan.
This publication specializes in the growth and precise discoveries within the interdisciplinary medical and technological zone of biomedical software of polymers. the subjects comprise polymeric fabrics for biomedical and pharmaceutical functions, in addition to polymeric fabrics in therapeutics.
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Although there are numerous reports concerning genetic and phenotype changes in tumors, there is as far as I know no pivotal change in tumor cells which distinguishes them from normal cells. I suppose that a subpopulation of dramatically changed tumors could be eradicated by the patients own immune system and then that subpopulation of tumors would be out of the question clinically. In general drugs, toxicity occurs at concentrations well above those needed to achieve maximum desired effect. So these drugs have a wide therapeutic window.
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However, oligonucleotides are unstable in the body and are not taken up very efficiently by the cells. Nanospheres could facilitate the uptake of oligonucleotides and also stabilise them against nuclease attack37. In a recently published study, Tondelli et al. have demonstrated a 50-fold greater intracellular delivery of an antisense oligonucleotide in HL60 leukemia cells using nanospheres compared to free oligonucleotide38. In this study, the Jasmine Davda et al. 27 oligonucleotide was bound to the outer surface of the nanospheres via ionic interactions.