Biophysics

Cancer Metastasis -- Related Genes (CANCER METASTASIS -- by D.R. Welch

Posted On March 24, 2017 at 12:37 pm by / Comments Off on Cancer Metastasis -- Related Genes (CANCER METASTASIS -- by D.R. Welch

By D.R. Welch

This quantity is the 1st try to summarize present wisdom in regards to the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. whereas all past authors tried to place their findings right into a context for translation to the medical scenario, the state-of-the-art doesn't absolutely let this as the box of metastasis is comparatively new. still, the contents of this quantity may be of use to participants of the melanoma examine neighborhood and clinicians drawn to constructing and imposing novel sorts of remedy for melanoma.

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E-cadherin downregulation in cancer: fuel on the fire? Mol Med Today 1999; 5:172-7. 47. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999; 285:1028-32. 48. Arbiser JL, Moses MA, Fernandez CA, et al. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A 1997; 94:861-6. 49. Holash J, Maisonpierre PC, Compton D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999; 284:1994-8. 50. Maniotis AJ, Folberg R, Hess A, et al.

The androgen-independent, fast growing human prostate cancer cell line, DU145, which serves as a model for advanced prostatic carcinoma, also exhibits constitutively active ERK2 activity. In addition, the androgen-insensitive, metastatic tumours exhibit low levels of E-cadherin, a cell adhesion molecule (79-81). Reintroduction of E-cadherin into prostate cancer cells that exhibit metastasis resulted in the attenuation of metastatic potential, in part by down regulating MMP2 activity (82). The MEK1/ERK pathway appears to play a role in the regulation of E-cadherin expression.

N Engl J Med 2000; 342:525-33. 23. Ebralidze A, Tulchinsky E, Grigorian M, et al. Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family. Genes Dev 1989; 3:1086-93. 24. Dear TN, Ramshaw IA, Kefford RF. Differential expression of a novel gene, WDNM1, in nonmetastatic rat mammary adenocarcinoma cells. Cancer Res 1988; 48:5203-9. 25. Dear TN, McDonald DA, Kefford RF.

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