Technology

Chip Technology by Sridhar Hannenhalli, Earl Hubbell, Robert Lipshutz, Pavel A.

Posted On March 23, 2017 at 8:35 am by / Comments Off on Chip Technology by Sridhar Hannenhalli, Earl Hubbell, Robert Lipshutz, Pavel A.

By Sridhar Hannenhalli, Earl Hubbell, Robert Lipshutz, Pavel A. Pevzner (auth.), Dr. Jörg Hoheisel, A. Brazma, K. Büssow, C. R. Cantor, F. C. Christians, G. Chui, R. Diaz, R. Drmanac, S. Drmanac, H. Eickhoff, K. Fellenberg, S. Hannenhalli, J. Hoheisel, A. Ho

DNA-chip research has come far because the first convention in Moscow in 1991. these days, DNA-microarrays appear to be a standard commodity in organic sciences. The complexity hidden in the back of the obvious ease of such reviews, even though, is highlighted via the truth that it took approximately ten years sooner than the technique fairly trigger. additionally, on nearer scrutiny, one realises that a few difficulties nonetheless stay. however, microarrays produce information on a scale past mind's eye many years in the past. The authors of the booklet took half in bringing this approximately. they're famous specialists within the box, many - like Edwin Southern, Hans Lehrach, Radoje Drmanac, Pavel Pevzner and Charles Cantor - were actively pursuing array expertise for greater than a decade. They display the continual improvement in either expertise and alertness parts and elucidate on serious issues that have to be thought of while appearing microarray analyses.

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McGall G, Labadie J, Brock P, Wallraff G, Nguyen T, Hinsberg W (1996) Proc Natl Acad Sci USA 93:13555 18. Wallraff G, Labadie J, Brock P, Nguyen T, Huynh T, Hinsberg W, McGall G (1997) Chemtech, February:22 19. Beecher JE, McGall GH, Goldberg MJ (1997) Preprints Am Chem Soc Div Polym Mater Sci Eng 76:597 20. Beecher JE, McGall GH, Goldberg MJ (1997) Preprints Am Chem Soc Div Polym Mater Sci Eng 77:394 21. Singh-Gasson S, Green RD, Yue Y, Nelson C, Blattner F, Sussman MR, Cerrina F (1999) Nat Biotechnol 17:974 22.

A radiolabeled or fluorescently tagged target sequence is hybridised to a scanning array and its interaction with the complementary oligonucleotides is displayed as a hybridisation signal. It is thus possible to determine the exact sequence and lengths of large numbers of interacting sequences in a single hybridisation experiment. We have found scanning arrays a useful tool not only to find effective antisense reagents, but also to study RNA folding and the mechanisms of heteroduplex formation.

Glass has a number of favourable properties including its easy availability, smooth surface, physical and chemical stability, and compatibility with the use of radiolabeled and fluorescently labeled targets. We have found that 3 mm window glass is a good material for array fabrication. To make the glass surface ready for chemical reaction with nucleotide precursors (standard nucleotide CE phosphoramidites), it is chemically derivatised with a 20-atom aliphatic chain to produce free hydroxyl groups on its surface [1].

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