Biophysics

Encyclopaedia of Biological Disaster Management: vol. 4. by Ranjeet Kumar Singh, Kumari Swarnim

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By Ranjeet Kumar Singh, Kumari Swarnim

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Lacrimation has also been observed in guinea pigs exposed to acetone vapors. Other Systemic Effects. No studies were located regarding other systemic effects in humans after inhalation exposure to acetone. Other systemic effects observed in animals after inhalation exposure to acetone include body weight changes. 05) reduced body weight gain from gestational day 14 onward and reduced extragestational body weight on gestational day 20 (NTP 1988). However, in a behavioral study, no effect on body weight gain was observed in female rats exposed to 16,000 ppm intermittently for 2 weeks.

As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. S. general population was found. The workers had been employed at the plant for at least 3 months to 23 years. Industrial hygiene surveys found that median time-weightedaverage acetone concentrations were 380, 770, and 1,070 ppm based on job categories.

Neurological Effects Case reports have described patients who became comatose or collapsed after hip casts were applied with acetone present in the setting fluid. In addition, a woman experienced headache, dizziness, weakness, difficulty speaking, and depression after a cast containing acetone had been applied. These patients had a strong odor of acetone in their breath, and acetone was detected in the urine and blood. These patients were exposed to acetone by inhalation during cast application and from evaporation from the casts after the applications.

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