Evolutionary Developmental Biology of the Cerebral Cortex by Novartis Foundation

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By Novartis Foundation

The cerebral cortex is the crowning success of evolution and the organic substrate of human psychological capacities. utilizing a comparative evolutionary developmental method of the learn of its foundation is helping to provide new insights into this advanced and demanding challenge. The comparability of immature phases finds positive aspects of evolution which are differently obstructed by way of the complexity of the mature mind, and the research of improvement by way of attainable evolutionary occasions is helping us to target the main biologically appropriate mechanisms. during this booklet, best specialists within the fields of mammalian, reptilian, avian and amphibian mind improvement and from evolutionary biology, take on the basic query of the foundation of the cerebral cortex. The publication contains severe examinations of tools used to review homology within the crucial apprehensive approach and strategies utilized in cladistic research. fresh info at the earliest generated brief cells within the mammalian, reptilian, avian and amphibian forebrain are mentioned, as are attainable homologies in response to particular connectional research. a few of the hypotheses at the starting place of the mammalian isocortex are mentioned intimately and new effects are offered on cortical association in reptiles, birds, marsupials, monotremes and different species.

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G. have affinity for the glial surface and strictly obey constraints imposed by transient radial glial scaffolding (RG). This cellular arrangement preserves relationships between the proliferative mosaic of the ventricular zone (VZ) and the corresponding proto-map within the SP and CP, even though the cortical surface in primates shifts considerably during a massive cerebral growth encountered in mid-gestation (for details see Rakic 1988). 34 RAKIC enables translation of two-dimensional positional information contained within of the mosaic of the proliferative zone into three-dimensional cortical architecture: the X and Y axis of cell position within the horizontal plane is provided by the site of cell origin; whereas the Z axis along the depth of the cortex is provided by the time of its origin.

Perhaps the most basic observation of all is that the cerebellum as a laminated cortex evolved in vertebrates well before its more anterior cousin, the cerebrum. Thus birds, reptiles, amphibia and several species of fish have significant layered cerebella at the midbrain/hindbrain junction, with most of the major cell types present. This earlier evolution may relate to the relative simplicity of the layering in the cerebellum compared to the cerebrum, although this is pure speculation. The THE CEREBELLUM 21 cerebellum is generally believed to have evolved from cells subserving the lateral line organ of fish, a somatosensory array that alerts the organism to the movement of the surrounding water.

We don't know why they go there, nor why they don't migrate caudally into the brainstem. Puelles: In my opinion, this interpretation is too simplistic, because in normal mice there is no direct connection between the cerebellum and the inferior colliculus, the whole isthmus being intercalated in between. This suggests that in this mutant there is a patterning defect that eliminates the isthmus altogether, in addition to a migratory defect. Molnar: I would like to suggest that perhaps the cerebellum is a good model for separating its different parts with different evolutionary origins.

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