Biophysics

Lung Biology in Health and Disease Volume 179 Acute by Michael A. Matthay

Posted On March 24, 2017 at 1:04 pm by / Comments Off on Lung Biology in Health and Disease Volume 179 Acute by Michael A. Matthay

By Michael A. Matthay

Forty-seven foreign experts give a contribution 23 chapters documenting fresh growth made within the examine of the extreme breathing misery syndrome (ARDS) and medical acute lung damage (ALI) on the molecular, mobile, and physiological degrees, and present pharmacological and ventilatory appro

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Larger multi-center epidemiological studies are necessary to determine whether these multiple conditions are truly independent predictors of mortality in ARDS. Since most ARDS patients do not die of persistent respiratory failure, it might not be surprising that initial indexes of oxygenation and ventilation, including the ratio and the lung injury score, do not predict outcome (79). The ARDSnet trial reported that the patients with improved survival due to low tidal volume ventilation actually had a worse ratio when compared to high tidal volume group.

Definitions and clinical risk factors 17 D. Future Directions Even after three consensus conferences and multiple studies, several issues still remain concerning the present diagnostic criteria for ARDS, including the heterogeneity of the patient population, the absence of a diagnostically accurate biochemical marker, and the lack of a reliable noninvasive measure of alveolar-capillary injury or permeability. Presently, ARDS can occur in a heterogeneous group of patients who develop common physiological and radiographic abnormalities.

Chest 1999; 116:1S-127S. 14. Rahman I, Macnee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 2000; 16:534–554. 15. Meduri GU. The role of the host defense response in the progression and outcome of ARDS: pathophysiological correlations and response to glucocorticoid treatment. Eur Respir J 1996; 9:2650–2670. 16. Bell RC, Coalson JJ, Smith JD, Johanson WG. Multiple organ system failure and infection in adult respiratory distress syndrome. Ann Intern Med 1983; 99:293–298.

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