Lung Biology in Health & Disease Volume 175 Oxygen Sensing: by Sukhamay Lahiri, Gregg Semenza, Nanduri R. Prabhakar
By Sukhamay Lahiri, Gregg Semenza, Nanduri R. Prabhakar
Reviewing study at the molecular foundation of oxygen homeostasis, this article describes the alterations in intracellular signalling and gene expression that result in physiological responses to hypoxia in unicellular, invertebrate, and mammalian species. It examines O2 sensing platforms in micro organism and archaea and demonstrates interrelationships between mobilephone proliferation, strength metabolism, oxygen homeostasis, redox states, sign transduction and gene expression in people and different organisms. The publication describes the impact of hypoxia on carotid physiology and serve as and the impression of adjustments in oxygen homeostasis at the pathophysiology of cardiac ischemia, melanoma, stroke, and persistent lung affliction.
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Does Chemoreception Fail After Destruction of Glomus Cells? Final Considerations on the Chemoreceptor Complex References Excitation of Glomus Cells: Interaction Between Voltage-Gated Kþ Channels and Cholinergic Receptors Machiko Shirahata, Tomoko Higashi, Serabi Hirasawa, Shigeki Yamaguchi, Robert S. Fitzgerald, and Boris Lande I. II. III. IV. 21. Introduction Methods Results and Discussion References From Oxygen Sensing to Chemosensory Activity: The Mediator Role of Glomus Cells Patricio Zapata I.
123 124 139 144 145 Introduction Hypoxia-Regulated Signal Transduction Pathways Hypoxia-Regulated Gene Expression: The EPAS-1 Story The Future: Identiﬁcation of the Hypoxia Genome References Regulation of Tyrosine Hydroxylase Gene Expression by Hypoxia in Neuroendocrine Cells Maria F. Czyzyk-Krzeska, Phillip O. Schnell, Amy L. Bauer, Justin B. Striet, James A. Nash, Anna V. Kuznetsova, and Anna S. Hui I. II. III. IV. V. VI. 10. Mechanisms of HIF-1a Activation Nonhypoxic Mechanisms of HIF-1 Activation HIF-1 Activation in Hypoxia and Ischemia During Aging Summary and Conclusions References Introduction Regulation of TH Gene Expression by Hypoxia in Catecholaminergic Cells Transcriptional Regulation of the TH Gene Hypoxia-Regulated Transcription Factors and Coactivators in Regulation of TH Gene Expression by Hypoxia Posttranscriptional Regulation of TH Gene Expression Role of pVhl in Regulation of TH Gene Expression References Genome-wide Computational Screen for Candidate HIF Target Genes in Drosophila melanogaster and Caenorhabditis elegans Thomas A.
IV. V. 23. Introduction Theory Methods Results Discussion References Nitric Oxide and Carotid Body Chemoreception: Multiple Target Sites Rodrigo Iturriaga and Julio Alcayaga I. II. III. IV. V. VI. 24. Carotid Body Neurotransmitters Cholinergic and Dopaminergic Receptors in the Cat Carotid Body Ach Regulates Its Own Release from Glomus Cells Nicotinic Action of Ach Appears to Regulate the Release of Catecholamines in Hypoxia-Challenged Cat Carotid Bodies Muscarinic Action of Ach Appears to Regulate the Release of Catecholamines in Hypoxia-Challenged Carotid Bodies Other Interrelationships Conclusion References Introduction Nitric Oxide Synthase Localization in the Carotid Body and Petrosal Ganglion Inhibitory Effects of NO on Carotid Body Chemoreception Target Sites and Mechanisms of NO Action in the Carotid Body Contribution of Endothelial and Neuronal NOS Isoforms Conclusions References Multiple Roles of Neurotransmitters in the Carotid Body: Involvement in Sensory Transmission and Adaptation to Hypoxia Ganesh K.