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Regulation of Isopentenoid Metabolism by W. David Nes, Edward J. Parish, James M. Trzaskos

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By W. David Nes, Edward J. Parish, James M. Trzaskos

content material: Biosynthesis and usage of isoprenoids : evaluation of study instructions / James M. Trzaskos --
legislation of monoterpene biosynthesis in conifer security / Efraim Lewinsohn, Mark Gijzen, and Rodney B. Croteau --
common rubber biosynthesis : a department of the isoprenoid pathway in crops / Katrina Cornish --
creation of normal carotenoids : impact and impression of biotechnology / Richard F. Taylor --
Prenylated amino acid composition of tissues / H.C. Rilling, L.M. Leining, E. Bruenger, D. Lever, and W.W. Epstein --
Isoprenylation of low molecular mass guanine nucleotide-binding proteins in mammalian cells / William A. Maltese, B. Therese Kinsella, and Kathleen M. Sheridan --
powerful, rationally designed inhibitors of squalene synthase / Scott A. Biller, Michael J. Sofia, Jeffrey W. Abt, Barbara DeLange, John okay. Dickson, Jr., Cornelia Forster, Eric M. Gordon, Thomas Harrity, David R. Magnin, Joseph Marretta, Lois C. wealthy, and Carl P. Ciosek, Jr. --
Oxysterol legislation of ldl cholesterol biosynthesis / F.R. Taylor --
Dual-action inhibitors of ldl cholesterol biosynthesis : lanosterol analogs that inhibit lanosterol 14[alpha]-methyl demethylase and suppress 3-hydroxy-3-methylglutaryl-coenzyme A reductase task / Leah L. Frye and Deborah A. Leonard --
legislation of sterol biosynthesis and its phylogenetic implications / Stephen R. Parker and W. David Nes --
Biosynthesis of oxysterols in crops, animals, and microorganisms / Edward J. Parish --
Enzyme platforms : use within the improvement of sterol biosynthesis inhibitors as agrochemicals / E.I. Mercer --
2,3-oxidosqualene cyclase and squalene epoxidase as aim enzymes for the improvement of recent sterol biosynthesis inhibitors / L. Cattel, M. Ceruti, G. Balliano, and F. Viola --
Squalene epoxidase inhibitors : structural determinants for task and selectivity of allylamines and similar compounds / Neil S. Ryder, Anton Stuetz, and Peter Nussbaumer --
Inhibition of sterol metabolism in bugs and nematodes / James A. Svoboda and David J. Chitwood --
Cytochrome P450-dependent 14[alpha]-demethylase : goal for antifungal brokers and herbicides / H. Vanden Bossche, P. Marichal, M-C. Coene, G. Willemsens, L. Le Jeune, W. Cools, and H. Verhoeven --
impact of tridemorph on sterol synthesis in algae / Glenn W. Patterson --
position of sphingomyelin in mobile ldl cholesterol homeostasis / Harry Rudney and Arun ok. Gupta --
Genetics and molecular biology of the genes functioning past due within the sterol biosynthetic pathway of Saccharomyces / Norman D. Lees, Beth A. Arthington, and Martin Bard.

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And enzymes (37). Carotenoids including bixin, crocetin and torularhodin were covalently bound i n dioxane or pyridine using carbodiimide or mixed anhydride coupling to a pressure stable hydroxymethacrylate support, Separon H E M A . Appropriate plant and animal extracts were then chromatographed on columns packed with the supports to isolate and purify carotenoid binding proteins. F o r example, Figure 5 illustrates the separation of a crocetin binding protein from extracts o f saffron and Crocus sp.

G. Bot. J . Linn. Soc. 1987, 94, 181 6. A. Israel J . Botany 1985, 34, 283 7. H. Phytochem 1991, 30, 2493 8. ; S. A. Plant Physiol. 1990, 92, 816 9. Berndt, J . S. Government Res. Rep. AD-601: 729 10. A. Phytochem. 1990, 29, 3809 11. A. J . Biol. Chem. 1989, 264, 18608 12. S. Biol. Chem. 1989, 264, 18589 13. Lynen, F. J . Rubber Res. Inst. Malays. 1969, 21, 389 14. R. Plant Physiol. 1989, 89, 506 15. McMullen, A. P. Biochem. J . 1966, 101, 42 16. D. Biochemistry 1988, 27, 7315 17. Tanaka, Y. Prog.

Besides genetic manipulation, new chemical regulators of carotenoid biosynthesis and isolated/immobilized enzyme systems are being developed for carotenoid production. Carotenoids are a ubiquitous and diverse class of natural pigments, functioning i n plants and microbes as photoprotective agents, as photosynthetic accessory pigments and as membrane stabilization components. In animals, carotenoids can function as a source of vitamin A and other retinoids or, as indicated by studies beginning i n the 1970s, photoprotective and cancer prevention agents Carotenoids are also indicated as protectants against lethal irradiation (4,5).

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