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Stem Cells And Regenerative Medicine by Walter C. Low

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By Walter C. Low

Stem cells have the capacity to differentiate into cells which are came across in the course of the physique. This basic estate of stem cells means that they could most likely be used to switch degenerative cells in the physique, and regenerate the useful skill of organ platforms that experience deteriorated as a result of ailment or getting older. This authoritative textbook presents an summary of the newest advances within the box of stem phone biology, spanning issues that come with nuclear reprogramming, somatic cellphone cloning, and determinants of mobile destiny; embryonic stem cells for hematopoietic and pancreatic fix; grownup stem cells for cardiovascular, neural, renal, and hepatic fix; and production of stem cells for scientific use.

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53. Sauvageau G, Thorsteinsdottir U, Eaves CJ, et al. (1995) Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9: 1753–1765. 54. Antonchuk J, Sauvageau G, Humphries RK. (2002) HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109: 39–45. qxd 3/29/2008 9:16 AM Page 24 FA 24 Stem Cells and Regenerative Medicine 55. Bowles KM, Vallier L, Smith JR, et al. (2006) HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells.

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1997) A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 386: 488–493. 41. Choi K, Kennedy M, Kazarov A, et al. (1998) A common precursor for hematopoietic and endothelial cells. Development 125: 725–732. qxd 3/29/2008 9:16 AM Page 23 FA 23 Development of Diverse Hematopoietic Cell Populations 42. Huber TL, Kouskoff V, Fehling HJ, et al. (2004) Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 432: 625–630. 43. Kennedy M, D’Souza SL, Lynch-Kattman M, et al.

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