Synthetic Bioabsorbable Polymers for Implants (ASTM Special by Chandra Mauli Agrawal, Jack E. Parr, and Steve T. Lin,
By Chandra Mauli Agrawal, Jack E. Parr, and Steve T. Lin, editors
12 papers supply an summary of using synthetics bioabsorbable polymers and handle the most recent matters surrounding their transforming into use together with: new purposes, try out and characterization ideas for uncooked fabrics and units, tissue engineering, efficacy, and long term results. various papers study: simple polymer homes and characterization, tissue engineering suggestions akin to implantation of a porous biodegradable scaffold on the disorder website within the tissue, and use of bioabsorbable polymers as replacements for metal fracture fixation units.
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This result was not significant. 8 (n = 8). Figure 9 : Prostacyclin (PGI2) and Thromboxane (TXA2) secretion by the luminal surfaces of the preclotted and PHO impregnated grafts after one month of implantation. Discussibn The present investigation was undertaken to assess the sterilization, degradation rate and biocompatibility of a bacterial polyester polyhydroxyoctanoate as a potential sealant for the polyester arterial prosthesis. The discussion which follows will examine the various physical and structural changes occurring after the sterilization of PHO, describe the mechanism and rate of degradation of PHO both in vitro and in vivo, and address the biocompatibility of PHO and its potential use for vascular surgery applications.
Our study also suggests the possible contribution of enzymes in the degradation of PHO, albeit to a lesser extent than the hydrolytic process. Enzymes secreted by inflammatory cells such as macrophages and FBGC may participate in the degradation process by isolating fragments of polymer, a phenomenon observed histologically. However, most of the polymer will be submitted to an hydrolytic process characterized by the gradual formation of low molecular fragments at which time, the enzymes may easily be involved as the final contributor to the degradation.
Investigation of the bulk chemistry of PHO revealed that gamma radiation induced a significant reduction of M w and M n, whereas no significant decrease in molecular weight was observed following EO sterilization. This phenomenon has been reported elsewhere with several degradable polymers [8-12]. The DSC results also revealed that the Tm and heat of fusion of the gamma-sterilization were modified after sterilization. The Tm was shown to have slightly decreased, which may be attributed to the decrease in the molecular weight or chain scission.