The Genetic Basis of Sleep and Sleep Disorders by Paul Shaw, Mehdi Tafti, Michael J. Thorpy
By Paul Shaw, Mehdi Tafti, Michael J. Thorpy
The 1st finished publication at the topic, The Genetic foundation of Sleep and Sleep issues covers designated studies of the overall ideas of genetics and genetic concepts within the research of sleep and sleep problems. The e-book comprises sections at the genetics of circadian rhythms, of standard sleep and wake states and of sleep homeostasis. There also are sections discussing the function of genetics within the knowing of insomnias, hypersomnias together with narcolepsy, parasomnias and sleep-related stream issues. the ultimate bankruptcy highlights using gene treatment in sleep issues. Written by way of genetic specialists and sleep experts from all over the world, the ebook is brand new and geared particularly to the desires of either researchers and clinicians with an curiosity in sleep medication. This ebook should be a useful source for sleep experts, neurologists, geneticists, psychiatrists and psychologists.
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Extra info for The Genetic Basis of Sleep and Sleep Disorders
Quantitative trait loci approach to the genetics of sleep in recombinant inbred mice. J Sleep Res. 1999;8(Suppl 1): 37–43. Darvasi A. Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet. 1998;18:19–24. One important caveat is that many resources have relatively limited genetic diversity, so they do not model a fully outbred population (like our own species). This drawback was addressed in the creation of the collaborative cross , which provides access to a more complete catalog of variation, and also has the advantage of allowing researchers to interrogate the same genotype multiple times.
Therefore, analyses of an HS have to take into account population structure, for example using mixed models. Second, as HS are derived from more than two progenitor strains, phenotypic variation needs to be mapped to the progenitor haplotypes. Commercial breeders maintain large populations of outbred mice and rats primarily for use by pharmaceutical companies. Many of the mouse stocks have been characterized  and show a very rapid decay of linkage disequilibrium (a requirement for very high mapping resolution) and few rare alleles (whose association with phenotypic variation is hard to detect in the current setting of genome-wide association studies), and are therefore very promising populations for QTL mapping (, and for a review of association studies that have used outbred stocks ).
A genomewide significance threshold can be obtained using permutations : the traits values and/or genotypes of all individuals are randomly reassigned (permuted), and association between each marker and the phenotype values is tested and the lowest P-value recorded. The procedure is repeated 1,000 times to obtain a distribution of the lowest P-values, from which a suitable quantile is extracted and used for comparison with each P-value obtained in the original (unpermuted) data set. Confidence intervals for the position of the QTL can be obtained by a bootstrap procedure : a large number of bootstrapped data sets are generated by sampling with replacement from the original data set and the position of the marker with the lowest P-value in the vicinity of the QTL of interest is recorded.