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Vitamin K by Gerald Litwack

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By Gerald Litwack

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Haematol. 126, 546–549. Sadler, J. E. (2004). Medicine: K is for koagulation. Nature 427, 493–494. , and Kamali, F. (2005). Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation. Thromb. Haemost. 93, 872–875. Spronk, H. , Soute, B. , Schurgers, L. , Thijssen, H. , De Mey, J. , and Vermeer, C. (2003). Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats.

274, 23963–23968. Morris, D. , Stevens, R. , Wright, D. , and Stafford, D. W. (1995). Processive posttranslational modification. Vitamin K-dependent carboxylation of a peptide substrate. J. Biol. Chem. 270, 30491–30498. , Bevans, C. , Muller, C. , and Watzka, M. (2006). Vitamin K epoxide reductase complex subunit 1 (VKORC1): The key protein of the vitamin K cycle. Antioxid. Redox Signal. 8, 347–353. Pelz, H. , Heiberg, A. , MacNicoll, A. , Prescott, C. , Walker, A. , and Muller, C. R. (2005). The genetic basis of resistance to anticoagulants in rodents.

These experimental results excluded the fat-soluble vitamins A, D, and E as the antihemorrhagic factor, so he proposed to name the new factor vitamin K (for Koagulation from the German and the Scandinavian languages). By carefully observing which foodstuffs alleviated the hemorraghic condition, the fat-soluble vitamin was found to be enriched in hog liver fat and hemp seed extracts, but its chemical nature and structure remained elusive. , 1939). , 1939). For the discovery of vitamin K, Dam was awarded the Nobel Prize in Physiology or Medicine in 1943; together with Doisy for the purification, characterization, and synthesis.

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